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Ninth-seeded former Wimbledon runner-up Marion Bartoli handled fellow Frenchwoman Virginie Razzano 7-5, 6-0, while German Sabine Lisicki, the 14th seed, advanced with a 6-2, 4-6, 6-4 win against Swiss Stefanie Voegele and 15th-seeded capable Russian Anastasia Pavlyuchenkova bested Czech Klara Zakopalova 7-6 (7-5), 6-1.
Other seeded victors on Day 2 were No. 23 Italian Roberta Vinci; No. 25 Estonian Kaia Kanepi; No. 27 Russian Maria Kirilenko; No. 29 Russian Nadia Petrova; and No. 30 German Angelique Kerber. Kanepi was a titlist in Brisbane two weeks ago.
The second round will get underway on Wednesday, including matches for world No. 1 Caroline Wozniacki, third-seeded Victoria Azarenka, fifth-seeded 2011 Aussie Open runner-up and French Open champion Li Na and 11th-seeded reigning Melbourne titlist Kim Clijsters.
Clijsters beat Li in last year's Aussie finale.
The 24-year-old Djokovic lost two of the first three games to Italy's Paolo Lorenzi, then won a whopping 17 in a row to finish off a commanding 6-2, 6-0, 6-0 win at the season's first Grand Slam event.
Meanwhile, a fourth-seeded Murray, who lost in straight sets to Djokovic in last year's Aussie final, needed four sets to down promising American Ryan Harrison, 4-6, 6-3, 6-4, 6-2.
Roddick's second-round opponent will be long-time rival and fellow former No. 1 Lleyton Hewitt.
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